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This study in its early stages and for valuable comments

9.6. Shneider NA, Brown MN, Smith CA, Pickel J, Alvarez FJ: Gamma motor neurons express distinct genetic markers at birth and require muscle spindle-derived GDNF for postnatal survival. Dasen JS: Transcriptional networks in the early development of sensory-motor circuits. Authors’ contributions FM and FH are co-senior authors. FH wrote the manuscript with proofreading by FM.

The contributions of the Region Provence Alpes C es d’Azur and Aix-Marseille Universit?for the IBDM animal facility, and of the France-BioImaging/PICsL infrastructure (ANR-10-INSB-04-01) for the imaging facility are also acknowledged.21. FH, NC, BH, FL and VA-G performed the experiments. Curr Top Dev Biol 2009, 87:119?48. 2.12.18.20. 3. Encinas M, Tansey MG, Tsui-Pierchala BA, MK-8353 Solubility Comella JX, Milbrandt J, Johnson EM Jr: c-Src is required for glial cell line-derived neurotrophic factor (GDNF) family ligand-mediated neuronal survival via a phosphatidylinositol-3 kinase (PI-3 K)-dependent pathway.Ing interests.14..10.17. J Neurosci 2011, 31:11144?1158. Work in the Helmbacher laboratory was supported by funds from the CNRS (ATIP grant), FRM (Fondation pour la Recherche M icale, Equipe FRM 2007), AFM (Association Fran ise contre les Myopathies), FdF (Fondation de France), ARC (Association pour la Recherche contre le Cancer) and ANR (Agence Nationale de la Recherche, ANR Neuro 2007). 7. FH and FM conceived, designed and directed the study, and analysed and interpreted the data.

Acknowledgements We thank Chris Henderson for invaluable intellectual support; Ruediger Klein for supporting this study in its early stages and for valuable comments on the manuscript, and former members of his laboratory for insightful discussion; Elise Arbeille for help with ISHs of spinal cord sections; Sylvie Richelme for technical help;

Virginia Girod-David and Leo Jullien for excellent help with mouse husbandry at the IBDM; and Angela Zimmermann for comments on the manuscript.13. Nat Rev Neurosci 2007, 8:331?40. Maina F, Pante G, Helmbacher F, Andres R, Porthin A, Davies AM, Ponzetto C, Klein R: Coupling Met to specific pathways results in distinct developmental outcomes. Kanning KC, Kaplan A, Henderson CE: Motor neuron diversity in development and disease.11.16. Final approval was given by all authors. Polleux F, Ince-Dunn G, Ghosh A: Transcriptional regulation of vertebrate axon guidance and synapse formation.22. Received: 1 July 2014 Accepted: 4 July4. Annu Rev Neurosci 2010, 33:409?40.19.15.5

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