The following table is the equivalent dose ratio of human, rat, and mouse based on body surface area: c. Beijing: China Medical Science and Technology Press, 2015. The value of i calculated by the above formula plus the logarithm of the dose in the lowest dose group (the first group can use the pre-experimental LD10 or LD0) is the logarithm of the dose in the second group (the second low-dose group), and so on to the highest dose Group (n group), find the antilog of each value to get the actual dose value of each dose group.6, and the ratio of adjacent doses is 1: 4.6, and then the antilogarithm is 40 mg / kg; and The logarithm of the next dose is 0. References: [1] Yuan Bojun,
Wang Zhiqiao. 3. pipette tips manufacturers is usually used to obtain the LD50 of the drug for reference. Long-term toxicity test: Considering the long period of long-term toxicity test, it can be carried out in the last step. This method is of reference value, but we must also pay attention to the similarities and differences of animals, especially when referring to the pharmacokinetic results of mice. Objective: To determine the therapeutic effects and general pharmacological effects of drugs, and to provide reliable evidence for clinical trials of new drugs
. The LD50 value of the drug that passes the acute toxicity test is designed based on the acute toxicity LD50 and long-term toxicity dose, which can be used as 1 / Similar doses of 10, 1/20, 1/30, or 1/40 are used as the high, medium, and low dose groups for pharmacodynamic experiments; the principle is that the dose for pharmacodynamic experiments should not be higher than the toxicology experimental dose. Beijing: Military Medical Science Press, 1997.
The proposed clinical dose method (ACD method) is calculated based on the same type of drugs or foreign data or the proposed clinical dose. Perform pharmacodynamic experiments: Generally, they can be designed according to the LD50 of the toxicity test. At first, it is not a specific number, but through the preliminary design range, and then through a variety of experimental investigations, to delineate the most suitable interval or a certain value. While observing the efficacy of the drug, you can observe some possible side effects, such as the effect on the hematopoietic system, liver and kidney toxicity lamp, and provide some references for the observation items of long-term toxicity experiments. This method can use fewer animals and drugs.
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